Ester-induced Delayed Neurotoxicity
نویسنده
چکیده
Most organophosphorus esters are direct inhibitors or are rapidly converted to inhibitors of acetylcholinesterase (AChE, EC 3.1.1.7) (1-3). Some of these compounds produce a more persistent effect: delayed neurotoxicity. In humans, organophosphorus ester-induced delayed neurotoxicity (OPIDN) results in a flaccid paresis which develops distally in the legs and spreads to the hands and thighs. In the later stages, symptoms of spinal cord injury such as spasticity and ataxia become evident as the symptoms of peripheral neuropathy recede. OPIDN has the following features:
منابع مشابه
Organophosphorus ester-induced chronic neurotoxicity.
Organophosphorus compounds are potent neurotoxic chemicals that are widely used in medicine, industry, and agriculture. The neurotoxicity of these chemicals has been documented in accidental human poisoning, epidemiological studies, and animal models. Organophosphorus compounds have 3 distinct neurotoxic actions. The primary action is the irreversible inhibition of acetylcholinesterase, resulti...
متن کامل484-497 Abou-donia Aug03
Organophosphorus compounds are potent neurotoxic chemicals that are widely used in medicine, industry, and agriculture. The neurotoxicity of these chemicals has been documented in accidental human poisoning, epidemiological studies, and animal models. Organophosphorus compounds have 3 distinct neurotoxic actions. The primary action is the irreversible inhibition of acetylcholinesterase, resulti...
متن کاملMitochondrial complex I inhibition as a possible mechanism of chlorpyrifos induced neurotoxicity
BACKGROUND Organophosphates (OPs) represent the most widely used class of pesticides. Although perceived as low toxicity compounds compared to the previous organochlorines, they still possess neurotoxic effects both on acute and delayed levels. Delayed neurotoxic effects of OPs include OPIDN and OPICN. The mechanisms of these delayed effects have not been totally unraveled yet. One possible con...
متن کاملAge-related differences in the inhibition of neuropathy target esterase and susceptibility to triphenyl phosphite-induced delayed neurotoxicity in chickens.
Triphenyl phosphite (TPP)-induced delayed neurotoxicity, which is thought to resemble but somewhat differ from classical organophosphate-induced delayed neurotoxicity (OPIDN), is known to be age-dependent. The relationship between clinical appearance and histopathological lesions, and the inhibition of neurotoxicity target esterase (NTE) in nervous tissues were compared in young and adult chick...
متن کاملThe Effect of Antioxidant Caffeic Acid Phenethyl Ester (cape) on Some Enzyme Activities in Cisplatin-induced Neurotoxicity in Rats
Caffeic acid phenethyl ester (CAPE), an active component of propolis extract, (1) has been synthesized by esterification of caffeic acid (2). At a concentration of 10 μM, it completely blocks production of reactive oxygen species (ROS) in human neutrophils and the xantine/xantine oxidase system (3). Besides its well-known antioxidant activity (2,4). CAPE inhibits certain enzyme activities such ...
متن کامل